Two years after defeating a satanic cult led by his babysitter Bee, Cole's trying to forget his past and focus on surviving high school. But when old enemies unexpectedly return, Cole will once again have to outsmart the forces of evil.

This time, the rivals team up to help a cowgirl and her brother save their homestead from a greedy land-grabber, and they’re going to need some help! Jerry’s three precocious nephews are all ready for action, and Tom is rounding up a posse of prairie dogs. But can a ragtag band of varmints defeat a deceitful desperado determined to deceive a damsel in distress? No matter what happens with Tom and Jerry in the saddle, it’ll be a rootin’ tootin’ good time!

A night of debauchery quickly turns rancid with the arrival of a fifth, unwanted guest.